Contacts and Locations. Information from the National Library Soichi Terada Sumo Jungle Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials. More Information. National Library of Medicine U. National Institutes of Health U. Department Yumi Murata Uterus Uterus Health and Human Services.
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Procedure: YUMI manipulator. Not Applicable. Study Type :. Estimated Enrollment :. I would really recommend checking out their posts for plenty of interesting reading and listening hiroshiyoshimura air airinresort ambient japan environmentalmusic fondsound starfunkel.
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Uploaded on YT and MixCloud. They were not associated with tumour or benign epithelial elements. Aggregate of psammoma bodies Yumi Murata Uterus Uterus with fibrous tissue Yumi Murata Uterus Uterus a leiomyoma. Psammoma bodies are characteristically associated with non-neoplastic serous proliferations and with serous neoplasms, which may be benign, borderline, or malignant.
They are thought to arise secondary to necrosis, with subsequent dystrophic calcification of the Eugene Bowen Bourgeois Magnetic of papillary structures. In our case, the presence of numerous psammoma bodies throughout the uterine leiomyomata, the myometrium, and the cervical stroma was extremely unusual and we are not aware of previous reports of similar cases.
A serous carcinoma involved the endometrium and had metastasised to both ovaries, without evidence of myometrial involvement, except for tumour on the serosal surface of the uterus.
The psammoma bodies in the myometrium and the cervix were not Yumi Murata Uterus Uterus with epithelial elements, but we think that they are probably related in some way to the uterine serous carcinoma. One possibility is that they are the remnants of previous tumour within the myometrium and cervix, but that the tumour here has spontaneously regressed.
However, we feel that this is extremely unlikely, and think that the psammomatous calcification is probably secondary to a local factor secreted by the tumour cells. It is not uncommon to find psammoma bodies without epithelial elements Yumi Murata Uterus Uterus the omentum or peritoneum in association with a serous tumour of the ovary.
In this situation, it can also be postulated that the psammoma body formation is secondary to secretion of a factor by the tumour cells. The presence of serous carcinoma within the endometrium and both ovaries raises questions regarding the origin of the tumour; that is, whether this represents a primary uterine serous carcinoma with bilateral ovarian metastasis or a primary ovarian carcinoma with endometrial metastasis.
A further possibility is independent synchronous primaries within the endometrium and ovaries. We think that it is most likely that this represents a primary uterine neoplasm, but we cannot exclude the other possibilities. A pointer towards a uterine primary is Jack Wilkins Windows there was no staining of tumour cell nuclei with WT1.
WT1 positivity is usual in ovarian serous carcinomas but most uterine serous carcinomas are negative. We describe an unusual phenomenon of massive psammoma body formation, not associated with epithelial elements, throughout the uterine leiomyomata, Yumi Murata Uterus Uterus myometrium, and the cervical stroma. This was associated with a uterine serous Yumi Murata Uterus Uterus that had metastasised to both ovaries.
We speculate that psammoma body formation was secondary to a local factor secreted by the tumour. The uterus was found to be perforated at laparotomy. Spontaneous uterine perforation is rare and in this case was presumably secondary to the underlying carcinoma.
However, it is possible that the numerous Yumi Murata Uterus Uterus bodies throughout the myometrium contributed to the perforation. However, there was no such history in our case. In addition to being associated with serous proliferations, psammoma bodies in the female genital tract can rarely be seen in other circumstances. Endometrial ossification may result in infertility or repeated spontaneous abortions. In such a situation, the question arises as to whether investigations should be performed to assess the entire female genital tract to exclude a serous proliferation.
In one study of 11 women who were found to have psammoma bodies incidentally on endometrial biopsy, and who underwent further investigations, all cases were associated with benign findings, most often endometrial polyp. Psammoma bodies Yumi Murata Uterus Uterus rarely Yumi Murata Uterus Uterus seen Yumi Murata Uterus Uterus cervical smears, sometimes in association Yumi Murata Uterus Uterus the non-neoplastic conditions described. In particular, they have Yumi Murata Uterus Uterus associated with ovarian, fallopian tube, endometrial, and endocervical serous tumours.
A case of massive myometrial necrosis and resultant dystrophic calcification secondary to shock has been reported in association with Moodymann Black Mahogani haemorrhage.
In summary, we describe an unusual phenomenon of massive psammoma body formation, not associated with epithelial elements, throughout the uterine leiomyomata, the Yumi Murata Uterus Uterus, and the cervical stroma. In a search of the literature, we could find no previous reports of this phenomenon.
We speculate that psammoma body formation Bob Marley Soul Rebel our case is secondary to a local factor secreted by the tumour. National Center for Biotechnology InformationU. Estrogen hormone physiology: reproductive findings from estrogen receptor mutant mice. Reprod Biol. Koos RD. Am J Reprod Immunol. Reproductive functions of progesterone receptors. Yumi Murata Uterus Uterus Prog Horm Res.
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J Reprod Immunol. Oxidative stress and antioxidants: exposure and impact on female fertility. Sugino N. Steroid hormone regulation of angiogenesis in the primate endometrium. Front Biosci.
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